Kesari Lab - UC San Diego
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1 News 256 Publications 25 Members

A 22-Year Old Woman with Right Eyelid Swelling.

van Vugt, Vincent A Kesari, Aditya Muller, Karra A Carter, Bob Vandenberg, Scott R Kesari, Santosh

Published in Brain pathology (Zurich, Switzerland)

Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies.

Xiu, Joanne Piccioni, David Juarez, Tiffany Pingle, Sandeep C Hu, Jethro Rudnick, Jeremy Fink, Karen Spetzler, David B Maney, Todd Ghazalpour, Anatole ...

Published in Oncotarget

Glioblastomas (GBM) are the most aggressive and prevalent form of gliomas with abysmal prognosis and limited treatment options. We analyzed clinically relevant molecular aberrations suggestive of response to therapies in 1035 GBM tumors. Our analysis revealed mutations in 39 genes of 48 tested. IHC revealed expression of PD-L1 in 19% and PD-1 in 46...

Leptomeningeal metastasis in breast cancer - a systematic review.

Scott, Brian J Oberheim-Bush, Nancy A Kesari, Santosh

Published in Oncotarget

There is limited data on the impact of specific patient characteristics, tumor subtypes or treatment interventions on survival in breast cancer LM. A systematic review was conducted to assess the impact of hormone receptor and HER-2 status on survival in breast cancer LM. A search for clinical studies published between 1/1/2007 and 7/1/2012 and all...

Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Cl... PDF available through Get Fulltext Research

Stupp, Roger Taillibert, Sophie Kanner, Andrew A Kesari, Santosh Steinberg, David M Toms, Steven A Taylor, Lynne P Lieberman, Frank Silvani, Antonio Fink, Karen L ...

Published in JAMA

Glioblastoma is the most devastating primary malignancy of the central nervous system in adults. Most patients die within 1 to 2 years of diagnosis. Tumor-treating fields (TTFields) are a locoregionally delivered antimitotic treatment that interferes with cell division and organelle assembly. To evaluate the efficacy and safety of TTFields used in ...

Cancer anti-angiogenesis vaccines: Is the tumor vasculature antigenically unique? PDF available through Get Fulltext Research

Wagner, Samuel C. Ichim, Thomas E. Ma, Hong Szymanski, Julia Perez, Jesus A. Lopez, Javier Bogin, Vladimir Patel, Amit N. Marincola, Francisco M. Kesari, Santosh ...

Published in Journal of Translational Medicine

Angiogenesis is essential for the growth and metastasis of solid tumors. The tumor endothelium exists in a state of chronic activation and proliferation, fueled by the tumor milieu where angiogenic mediators are aberrantly over-expressed. Uncontrolled tumor growth, immune evasion, and therapeutic resistance are all driven by the dysregulated and co...

Recovery of Drug Delivery Nanoparticles from Human Plasma Using an Electrokinetic Platform Technology.

Ibsen, Stuart Sonnenberg, Avery Schutt, Carolyn Mukthavaram, Rajesh Yeh, Yasan Ortac, Inanc Manouchehri, Sareh Kesari, Santosh Esener, Sadik Heller, Michael J ...

Published in Small (Weinheim an der Bergstrasse, Germany)

The effect of complex biological fluids on the surface and structure of nanoparticles is a rapidly expanding field of study. One of the challenges holding back this research is the difficulty of recovering therapeutic nanoparticles from biological samples due to their small size, low density, and stealth surface coatings. Here, the first demonstrat...

Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres PDF available through Get Fulltext Research

Mukthavaram, Rajesh Ouyang, Xiao Saklecha, Rohit Jiang, Pengfei Nomura, Natsuko Pingle, Sandeep C Guo, Fang Makale, Milan Kesari, Santosh

Published in Journal of Translational Medicine

BackgroundThe STAT3 transcription factor is a major intracellular signaling protein and is frequently dysregulated in the most common and lethal brain malignancy in adults, glioblastoma multiforme (GBM). Activation of STAT3 in GBM correlates with malignancy and poor prognosis. The phosphorylating signal transducer JAK2 activates STAT3 in response t...

Insecticide susceptibility of Phlebotomus argentipes & assessment of vector control in two districts of West Bengal, Ind...

Kumar, Vijay Shankar, Lokesh Kesari, Shreekant Bhunia, Gouri Shankar Dinesh, Diwakar Singh Mandal, Rakesh Das, Pradeep

Published in The Indian journal of medical research

Kala-azar or visceral leishmanisis (VL) is known to be endemic in several States of India including West Bengal (WB). Only meager information is available on the vector dynamics of its vector species, Phlebotomus argentipes particularly in relation to control measure from this State. Hence, a pilot study was undertaken to assess the control strateg...

Glucose-corrected standardized uptake value in the differentiation of high-grade glioma versus post-treatment changes.

Nozawa, Asae Rivandi, Ali Hosseini Kanematsu, Masayuki Hoshi, Hiroaki Piccioni, David Kesari, Santosh Hoh, Carl K

Published in Nuclear medicine communications

These results suggest that SUV(gluc) may aid in the differentiation of residual or recurrent high-grade tumor from post-treatment changes in patients with abnormal blood glucose levels. The simplicity of the SUV(gluc) avoids the complexity of kinetic analysis or the requirement of a reference tissue.

Induction of tumor inhibitory anti-angiogenic response through immunization with interferon Gamma primed placental endot... PDF available through Get Fulltext Research

Ichim, Thomas E Li, Shuang Ma, Hong Yurova, Yuliya V Szymanski, Julia S Patel, Amit N Kesari, Santosh Min, Wei-Ping Wagner, Samuel C

Published in Journal of Translational Medicine

BackgroundWhile the concept of angiogenesis blockade as a therapeutic intervention for cancer has been repeatedly demonstrated, the full promise of this approach has yet to be realized. Specifically, drugs such as VEGF-blocking antibodies or kinase inhibitors suffer from the drawbacks of resistance development, as well as off-target toxicities. Pre...

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