Kesari Lab - UC San Diego
  • Upload

  • Log in

  • Sign up

Search on MyScienceWork
1 News 256 Publications 25 Members

Phase 2 study of CT-322, a targeted biologic inhibitor of VEGFR-2 based on a domain of human fibronectin, in recurrent g...

Schiff, David Kesari, Santosh de Groot, John Mikkelsen, Tom Drappatz, Jan Coyle, Thomas Fichtel, Lisa Silver, Bruce Walters, Ian Reardon, David ...

Published in Investigational New Drugs

VEGF signaling through VEGFR-2 is the major factor in glioblastoma angiogenesis. CT-322, a pegylated protein engineered from the 10th type III human fibronectin domain, binds the VEGFR-2 extracellular domain with high specificity and affinity to block VEGF-induced VEGFR-2 signaling. This study evaluated CT-322 in an open-label run-in/phase 2 settin...

Overcoming tumor immune evasion with an unique arbovirus PDF available through Get Fulltext Research

Lyday, Bruce Chen, Tony Kesari, Santosh Minev, Boris

Published in Journal of Translational Medicine

Combining dendritic cell vaccination with the adjuvant effect of a strain of dengue virus may be a way to overcome known tumor immune evasion mechanisms. Dengue is unique among viruses as primary infections carry lower mortality than the common cold, but secondary infections carry significant risk of hypovolemic shock. While current immuno-therapie...

Asymptomatic Leishmania infections in northern India: a threat for the elimination programme?

Das, Sushmita Matlashewski, Greg Bhunia, Gouri Sankar Kesari, Sreekanth Das, Pradeep

Published in Transactions of the Royal Society of Tropical Medicine and Hygiene

Visceral leishmaniasis (VL) continues to embody as a mammoth public health problem and hurdle to the socioeconomic development of Bihar, India. Interestingly, all leishmanial infections do not lead to overt clinical disease and may stay asymptomatic for a period of time. Asymptomatic cases of VL are considered as probable potential reservoirs of VL...

Diffusion-weighted imaging in cancer: physical foundations and applications of restriction spectrum imaging.

White, Nathan S McDonald, Carrie McDonald, Carrie R Farid, Niky Kuperman, Josh Karow, David Schenker-Ahmed, Natalie M Bartsch, Hauke Rakow-Penner, Rebecca Holland, Dominic ...

Published in Cancer research

Diffusion-weighted imaging (DWI) has been at the forefront of cancer imaging since the early 2000s. Before its application in clinical oncology, this powerful technique had already achieved widespread recognition due to its utility in the diagnosis of cerebral infarction. Following this initial success, the ability of DWI to detect inherent tissue ...

An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII.

Li, L Chakraborty, S Yang, C-R Hatanpaa, K J Cipher, D J Puliyappadamba, V T Rehman, A Jiwani, A J Mickey, B Madden, C ...

Published in Oncogene

EGFRvIII is a key oncogene in glioblastoma (GBM). EGFRvIII results from an in-frame deletion in the extracellular domain of EGFR, does not bind ligand and is thought to be constitutively active. Although EGFRvIII dimerization is known to activate EGFRvIII, the factors that drive EGFRvIII dimerization and activation are not well understood. Here we ...

Concurrent intrathecal methotrexate and liposomal cytarabine for leptomeningeal metastasis from solid tumors: a retrospe...

Scott, Brian J. van Vugt, Vincent A. Rush, Toni Brown, Tiffany Chen, Clark C. Carter, Bob S. Schwab, Richard Fanta, Paul Helsten, Teresa Bazhenova, Lyudmila ...

Published in Journal of Neuro-Oncology

Leptomeningeal metastasis (LM) from solid tumors is typically a late manifestation of systemic cancer with limited survival. Randomized trials comparing single agent intrathecal methotrexate to liposomal cytarabine have shown similar efficacy and tolerability. We hypothesized that combination intrathecal chemotherapy would be a safe and tolerable o...

Targeting and depletion of circulating leukocytes and cancer cells by lipophilic antibody-modified erythrocytes.

Mukthavaram, Rajesh Shi, Guixin Kesari, Santosh Simberg, Dmitri

Published in Journal of controlled release : official journal of the Controlled Release Society

There is a great interest in targeting and selective ablation of populations of circulating cells for research or therapeutic purposes. Red blood cells (RBCs) are readily available and fully biocompatible long-circulating intravascular carriers (natural life is 120days) that are amenable to chemical modifications, drug loading and reinjection. Here...

In silico modeling predicts drug sensitivity of patient-derived cancer cells PDF available through Get Fulltext Research

Pingle, Sandeep C Sultana, Zeba Pastorino, Sandra Jiang, Pengfei Mukthavaram, Rajesh Chao, Ying Bharati, Ila Sri Nomura, Natsuko Makale, Milan Abbasi, Taher ...

Published in Journal of Translational Medicine

BackgroundGlioblastoma (GBM) is an aggressive disease associated with poor survival. It is essential to account for the complexity of GBM biology to improve diagnostic and therapeutic strategies. This complexity is best represented by the increasing amounts of profiling (“omics”) data available due to advances in biotechnology. The challenge of int...

Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases PDF available through Get Fulltext Research

Nomura, Natsuko Pastorino, Sandra Jiang, Pengfei Lambert, Gage Crawford, John R Gymnopoulos, Marco Piccioni, David Juarez, Tiffany Pingle, Sandeep C Makale, Milan ...

Published in Cancer Cell International

BackgroundPrimary and secondary brain cancers are highly treatment resistant, and their marked angiogenesis attracts interest as a potential therapeutic target. Recent observations reveal that the microvascular endothelium of primary high-grade gliomas expresses prostate specific membrane antigen (PSMA). Breast cancers express PSMA and they frequen...

Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs PDF available through Get Fulltext Research

Jiang, Pengfei Mukthavavam, Rajesh Chao, Ying Bharati, Ila Sri Fogal, Valentina Pastorino, Sandra Cong, Xiuli Nomura, Natsuko Gallagher, Matt Abbasi, Taher ...

Published in Journal of Translational Medicine

BackgroundGlioblastoma (GBM) is a therapeutic challenge, associated with high mortality. More effective GBM therapeutic options are urgently needed. Hence, we screened a large multi-class drug panel comprising the NIH clinical collection (NCC) that includes 446 FDA-approved drugs, with the goal of identifying new GBM therapeutics for rapid entry in...

  • ← Previous
  • 1
  • 2 (current)
  • 3
  • 4
  • 5
  • …
  • 22
  • Next →
Powered by Polaris
  • About the Lab
  • Our Research
  • FAQ