Clinical trials of viral therapy for malignant gliomas.

Published in Expert Review of Anticancer Therapy

Despite recent scientific advances in the understanding of the biology of malignant gliomas, there has been little change in the overall survival for this devastating disease. New and innovative treatments are under constant investigation. Starting in the 1990s, there was an interest in using viral therapeutics for the treatment of malignant glioma...

Distearoyl anchor-painted erythrocytes with prolonged ligand retention and circulation properties in vivo.

Published in Advanced Healthcare Materials

Red blood cells (RBCs) attract significant interest as carriers of biomolecules, drugs, and nanoparticles. In this regard, versatile technologies to attach molecules and ligands to the RBC surface are of great importance. Reported here is a fast and efficient surface painting strategy to attach ligands to the surface of RBCs, and the factors that c...

A pilot safety study of lenalidomide and radiotherapy for patients with newly diagnosed glioblastoma multiforme.

Published in International Journal of Radiation Oncology*Biology*Physics

Toxicity and neuronal infection of a HSV-1 ICP34.5 mutant in nude mice.

Published in Journal of NeuroVirology

HSV-1 mutants in the RL-1 gene encoding the ICP34.5 protein have been demonstrated to have diminished neurovirulence in brain yet replicate as efficiently as parental virus in transformed tissue culture cells. Thus they have been proposed as candidates viruses for human brain tumor therapies. Evaluation of their replicative properties and pathogene...

Development of NG2 neural progenitor cells requires Olig gene function.

Published in Proceedings of the National Academy of Sciences

In the adult central nervous system, two distinct populations of glial cells expressing the chondroitin sulfate proteoglycan NG2 have been described: bipolar progenitor cells and more differentiated "synantocytes." These cells have diverse neurological functions, including critical roles in synaptic transmission, repair, and regeneration. Despite t...

Progressive multifocal leukoencephalopathy in a patient with relapsed acute myelogenous leukemia.

Published in Journal of Clinical Oncology

Medical management of patients with brain tumors.

Published in Journal of Neuro-Oncology

The most common medical problems in brain tumor patients include the management of seizures, peritumoral edema, medication side effects, venous thromboembolism (VTE), fatigue and cognitive dysfunction. Despite their importance, there are relatively few studies specifically addressing these issues. There is increasing evidence that brain tumor patie...