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1 News 256 Publications 25 Members

Understanding the origins of gliomas and developing novel therapies: cerebrospinal fluid and subventricular zone interpl...

Glantz, M Santosh Kesari Recht, L Fleischhack, G Van Horn, A

Published in Seminars in Oncology

Glioblastoma multiforme (GBM), the most common malignant primary brain tumor in adults, carries a poor prognosis, with median survival generally less than 1 year. Although initial therapy often eradicates the bulk of the tumor, disease recurrence, usually within 2 cm of the original tumor, is almost inevitable. This may be due to a failure of curre...

Distearoyl anchor-painted erythrocytes with prolonged ligand retention and circulation properties in vivo.

Shi, G Rajesh Mukthavaram Santosh Kesari Simberg, D

Published in Advanced Healthcare Materials

Red blood cells (RBCs) attract significant interest as carriers of biomolecules, drugs, and nanoparticles. In this regard, versatile technologies to attach molecules and ligands to the RBC surface are of great importance. Reported here is a fast and efficient surface painting strategy to attach ligands to the surface of RBCs, and the factors that c...

A pilot safety study of lenalidomide and radiotherapy for patients with newly diagnosed glioblastoma multiforme.

Drappatz, J Wong, Et Schiff, D Santosh Kesari Batchelor, Tt Doherty, L Lafrankie, Dc Ramakrishna, N Weiss, S Smith, St ...

Published in International Journal of Radiation Oncology*Biology*Physics

Toxicity and neuronal infection of a HSV-1 ICP34.5 mutant in nude mice.

Lasner, Tm Tal-Singer, R Santosh Kesari Lee, Vm Trojanowski, Jq Fraser, Nw

Published in Journal of NeuroVirology

HSV-1 mutants in the RL-1 gene encoding the ICP34.5 protein have been demonstrated to have diminished neurovirulence in brain yet replicate as efficiently as parental virus in transformed tissue culture cells. Thus they have been proposed as candidates viruses for human brain tumor therapies. Evaluation of their replicative properties and pathogene...

Development of NG2 neural progenitor cells requires Olig gene function.

Ligon, Kl Santosh Kesari Kitada, M Sun, T Arnett, Ha Alberta, Ja Anderson, Dj Stiles, Cd Rowitch, Dh

Published in Proceedings of the National Academy of Sciences

In the adult central nervous system, two distinct populations of glial cells expressing the chondroitin sulfate proteoglycan NG2 have been described: bipolar progenitor cells and more differentiated "synantocytes." These cells have diverse neurological functions, including critical roles in synaptic transmission, repair, and regeneration. Despite t...

Progressive multifocal leukoencephalopathy in a patient with relapsed acute myelogenous leukemia.

Santosh Kesari Akar, S Saad, A Drappatz, J Koralnik, Ij Deangelo, Dj

Published in Journal of Clinical Oncology

Medical management of patients with brain tumors.

Wen, Py Schiff, D Santosh Kesari Drappatz, J Gigas, Dc Doherty, L

Published in Journal of Neuro-Oncology

The most common medical problems in brain tumor patients include the management of seizures, peritumoral edema, medication side effects, venous thromboembolism (VTE), fatigue and cognitive dysfunction. Despite their importance, there are relatively few studies specifically addressing these issues. There is increasing evidence that brain tumor patie...

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