Kesari Lab - UC San Diego
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1 News 256 Publications 25 Members

The extrinsic coagulation cascade and tissue factor pathway inhibitor in macrophages: A potential therapeutic opportunit...

Jiang, Pengfei Xue, Dong Zhang, Yingjia Ye, Longwu Liu, Yuan Makale, Milan Kesari, Santosh Edgington, Thomas S. Liu, Cheng

Published in Thrombosis Research

ObjectivesThe coagulation protease cascade plays the central requisite role in initiation of arterial atherothrombosis. However, the relative participation of the extrinsic as compared to the intrinsic pathway is incompletely resolved. We have investigated in vivo the relative importance of the extrinsic and intrinsic pathways to define which is mo...

78 year old male with dysphagia and dysarthria.

Mahta, Ali Du, Zhongde Borys, Ewa Carter, Bob Vandenberg, Scott R Kesari, Santosh

Published in Brain pathology (Zurich, Switzerland)

PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression

Muh, Carrie R. Joshi, Shweta Singh, Alok R. Kesari, Santosh Durden, Donald L. Makale, Milan T.

Published in Journal of Neuro-Oncology

Glioblastoma (GBM) is the most common brain cancer and is highly lethal in both adults and children. 2-methoxyestradiol (2ME2) is a microtubule inhibitor that potently inhibits HIF1α, GBM angiogenesis and tumor growth in preclinical models. In patients, 2ME2 exhibits low toxicity and promising but inconsistent efficacy. Given its preclinical potenc...

Restriction-Spectrum Imaging of Bevacizumab-Related Necrosis in a Patient with GBM PDF available through Get Fulltext Research

Farid, Nikdokht Almeida-Freitas, Daniela B. White, Nathan S. McDonald, Carrie R. Muller, Karra A. VandenBerg, Scott R. Kesari, Santosh Dale, Anders M.

Published in Frontiers in Oncology

Importance: With the increasing use of antiangiogenic agents in the treatment of high-grade gliomas, we are becoming increasingly aware of distinctive imaging findings seen in a subset of patients treated with these agents. Of particular interest is the development of regions of marked and persistent restricted diffusion. We describe a case with hi...

Determinants of respiratory diseases in East Sikkim PDF available through Get Fulltext Research

Barua, Ankur Tiwari, VK Kesari, Santosh P

Published in BMC Research Notes

BackgroundDue to the difficult geographic terrain with lack of roads and transport, the Sikkim State in India finds difficulties in contending the respiratory diseases especially during the rainy seasons.FindingsA case–control study was conducted for two months at the Central Referral Hospital of East Sikkim involving 110 individuals in the age gro...

Longitudinal restriction spectrum imaging is resistant to pseudoresponse in patients with high-grade gliomas treated wit...

Kothari, Pranay White, Nathan S Farid, Nikdokht Chung, Romy Kuperman, Joshua M Girard, Holly M Shankaranarayanan, Ajit Kesari, Santosh McDonald, Carrie R Dale, Anders M ...

Published in AJNR. American journal of neuroradiology

Antiangiogenic therapies, such as bevacizumab, decrease contrast enhancement and FLAIR hyperintensity in patients with high-grade gliomas in a manner that may not correlate with actual tumor response. This study evaluated the ability of an advanced DWI technique, restriction spectrum imaging, to improve conspicuity within regions of restricted diff...

Retrospective study of pemetrexed as salvage therapy for central nervous system lymphoma

Zhang, Jun-Ping Lee, Eudocia Q. Nayak, Lakshmi Doherty, Lisa Kesari, Santosh Muzikansky, Alona Norden, Andrew D. Chen, Huichao Wen, Patrick Y. Drappatz, Jan ...

Published in Journal of Neuro-Oncology

There is currently no standard therapy for recurrent or chemotherapy-refractory central nervous system lymphoma (CNSL). Pemetrexed has been reported to have activity in patients with primary CNSL (PCNSL). The use of pemetrexed in secondary CNS lymphoma (SCNSL) has not previously been reported. Here we retrospectively review the outcomes and toxicit...

Pattern of Nonmelanoma Skin Cancers in Sikkim, India: A 3-year Clinicopathological Review

Baruah, Binayak Sengupta, Subhabrata Kesari, Santosh P. Ilapakurty, Bhargaw

Published in Indian Journal of Otolaryngology and Head & Neck Surgery

Basal cell carcinoma (BCC) and Squamous cell carcinoma (SCC), in combination, are referred to as Nonmelanoma skin cancers (NMSCs). NMSC has not been extensively studied in the population of the North eastern India as it has been done in the rest of India. This study was performed to understand the pattern of NMSCs in head and neck region in Sikkime...

Glucose corrected standardized uptake value (SUVgluc) in the evaluation of brain lesions with 18F-FDG PET

Nozawa, Asae Rivandi, Ali Hosseini Kesari, Santosh Hoh, Carl K.

Published in European Journal of Nuclear Medicine and Molecular Imaging

PurposeTo retrospectively assess the utility of 18F fluorodeoxyglucose (FDG) positron emission tomography (PET) images of standardized uptake values corrected for blood glucose (SUVgluc), and to compare this to various quantitative methods to identify the presence or absence of high grade malignancy.MethodsA retrospective review in 42 patients, fou...

Anatomical Variations of Uncinate Process Observed in Chronic Sinusitis

Tuli, Isha Preet Sengupta, Subhabrata Munjal, Sudeep Kesari, Santosh Prasad Chakraborty, Suvamoy

Published in Indian Journal of Otolaryngology and Head & Neck Surgery

Chronic Sinusitis, an extremely persistent illness, is surgically best treated by Functional Endoscopic Sinus Surgery. The ostiomeatal complex is the main area targeted and within it uncinate process is the first anatomical structure encountered. The significance of anatomical variations concerning age and sex of uncinate process in chronic sinusit...

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