Multifocal CNS infiltration of chronic lymphocytic leukemia in the form of small-cell solid metastatic lesions
Published in Journal of Neuro-Oncology
Sellar and supra-sellar glioblastoma masquerading as a pituitary macroadenoma
Published in Neurological Sciences
A few number of suprasellar gliomas have been reported thus far of which, some of them developed several years after radiation therapy for pituitary adenomas or craniopharyngiomas. Herein, we report a case of sellar glioblastoma with suprasellar extension with no prior radiation history who mimicked clinical and radiologic findings of a pituitary m...
Late temporal lobe necrosis after conventional radiotherapy for carcinoma of maxillary sinus
Published in Medical Oncology
Cerebral radiation necrosis is a serious late complication after conventional radiotherapy that can present with focal neurologic deficits or with more generalized signs and symptoms of increased intracranial pressure, depending on the location. The incidence and severity of radionecrosis are dose-volume dependent. We report a case of cerebral radi...
Novel approaches to treating leptomeningeal metastases
Published in Journal of Neuro-Oncology
Leptomeningeal metastasis is a devastating complication of the central nervous system in patients with late-stage solid or hematological cancers. Leptomeningeal metastasis results from the multifocal seeding of the leptomeninges by malignant cancer cells. Although central nervous system metastasis usually presents in patients with widely disseminat...
Paraganglioma with intracranial metastasis: a case report and review of the literature
Published in Neurological Sciences
Paragangliomas are rare neuroendocrine tumors of neural crest origin. They are mostly benign, however; malignant tumors with aggressive behavior and distant metastasis can also occur. Intracranial involvement is extremely rare and has been sporadically reported in the literature. Here we report a case who presented with progressive neurologic defic...
Patterns of imaging failures in glioblastoma patients treated with chemoradiation: a retrospective study
Published in Medical Oncology
Glioblastoma multiforme (GBM) is the most common primary brain tumor of adults and carries a poor prognosis. This study sought to investigate recurrence patterns of GBM treated with temozolomide-based chemoradiation. Records for 31 patients treated for newly diagnosed GBM between 2007 and 2009 were retrospectively analyzed. Ten patients received ma...
Genomic profiling of glioblastoma: convergence of fundamental biologic tenets and novel insights
Published in Journal of Neuro-Oncology
With advances in genomic profiling and sequencing technology, we are beginning to understand the landscape of the genetic events that accumulated during the neoplastic process. The insights gleamed from these genomic profiling studies with regards to glioblastoma etiology has been particularly satisfying because it cemented the clinical pertinence ...
Cerebellar glioneuronal tumor: a case report and review of the literature
Published in Medical Oncology
Progressive Multifocal Leukoencephalopathy with Wallerian Degeneration
Published in European Neurology
Relapsing Tumefactive Lesion in an Adult with Medulloblastoma Previously Treated with Chemoradiotherapy and Stem Cell Tr...
Published in Pathology & Oncology Research
Herein, we present an adult case of medulloblastoma who received chemotherapy, radiation therapy and stem cell transplantation, and underwent multiple surgical resections for what were thought to be recurrences; however pathology confirmed a diagnosis of relapsing tumefactive lesions. This phenomenon seems to be a consequence of stem cell transplan...
