Kesari Lab - UC San Diego
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1 News 256 Publications 25 Members

Protein interaction discovery using parallel analysis of translated ORFs (PLATO).

Zhu, Jian Larman, H Benjamin Gao, Geng Somwar, Romel Zhang, Zijuan Laserson, Uri Ciccia, Alberto Pavlova, Natalya Church, George Zhang, Wei ...

Published in Nature biotechnology

Identifying physical interactions between proteins and other molecules is a critical aspect of biological analysis. Here we describe PLATO, an in vitro method for mapping such interactions by affinity enrichment of a library of full-length open reading frames displayed on ribosomes, followed by massively parallel analysis using DNA sequencing. We d...

Swedish review strengthens grounds for concluding that radiation from cellular and cordless phones is a probable human c...

Davis, Devra Lee Kesari, Santosh Soskolne, Colin L Miller, Anthony B Stein, Yael

Published in Pathophysiology : the official journal of the International Society for Pathophysiology

With 5.9 billion reported users, mobile phones constitute a new, ubiquitous and rapidly growing exposure worldwide. Mobile phones are two-way microwave radios that also emit low levels of electromagnetic radiation. Inconsistent results have been published on potential risks of brain tumors tied with mobile phone use as a result of important methodo...

Sellar and supra-sellar glioblastoma masquerading as a pituitary macroadenoma

Mahta, Ali Buhl, Ralf Huang, Hongguang Jansen, Olav Kesari, Santosh Ulmer, Stephan

Published in Neurological Sciences

A few number of suprasellar gliomas have been reported thus far of which, some of them developed several years after radiation therapy for pituitary adenomas or craniopharyngiomas. Herein, we report a case of sellar glioblastoma with suprasellar extension with no prior radiation history who mimicked clinical and radiologic findings of a pituitary m...

47-year-old man with left leg numbness.

Mahta, Ali Kim, Ryan Y Saad, Ali G Kesari, Santosh

Published in Brain pathology (Zurich, Switzerland)

A 47-year-old white male with a history of uveitis, hypercalcemia and nephrolithiasis presented with acute onset partial seizure. On exam he had decreased sensation to light touch on his left lower extremity. A Brain MRI revealed a right frontal mass, which was initially thought to be a metastatic lesion or a primary brain tumor. However, biopsy of...

Isolation of rare tumor cells from blood cells with buoyant immuno-microbubbles. PDF available through Get Fulltext Research

Shi, Guixin Cui, Wenjin Benchimol, Michael Liu, Yu-Tsueng Mattrey, Robert F Mukthavaram, Rajesh Kesari, Santosh Esener, Sadik C Simberg, Dmitri

Published in PloS one

Circulating tumor cells (CTCs) are exfoliated at various stages of cancer, and could provide invaluable information for the diagnosis and prognosis of cancers. There is an urgent need for the development of cost-efficient and scalable technologies for rare CTC enrichment from blood. Here we report a novel method for isolation of rare tumor cells fr...

Recovery of white matter tracts in regions of peritumoral FLAIR hyperintensity with use of restriction spectrum imaging....

McDonald, C R White, N S Farid, N Lai, G Kuperman, J M Bartsch, H Hagler, D J Kesari, S Carter, B S Chen, C C ...

Published in AJNR. American journal of neuroradiology

DTI is being increasingly used to visualize critical white matter tracts adjacent to brain tumors before neurosurgical resection. However, brain tumors, particularly high-grade gliomas, are typically surrounded by regions of FLAIR hyperintensity that include edema, which increase isotropic diffusion, degrading the ability of standard DTI to uncover...

High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor resp... PDF available through Get Fulltext Research

Mukthavaram, Rajesh Jiang, Pengfei Saklecha, Rohit Simberg, Dmitri Bharati, Ila Sri Nomura, Natsuko Chao, Ying Pastorino, Sandra Pingle, Sandeep C Fogal, Valentina ...

Published in International journal of nanomedicine

Staurosporine (STS) is a potent pan-kinase inhibitor with marked activity against several chemotherapy-resistant tumor types in vitro. The translational progress of this compound has been hindered by poor pharmacokinetics and toxicity. We sought to determine whether liposomal encapsulation of STS would enhance antitumor efficacy and reduce toxicity...

Cerebral syphilitic gumma: a case report and review of the literature

Li, Jing-cheng Mahta, Ali Kim, Ryan Y. Saria, Marlon Kesari, Santosh

Published in Neurological Sciences

A 45-year-old male presented with subacute onset of a right-sided hemiparesis, right homonymous hemianopsia, and slurred speech. The brain imaging revealed two separate intraparenchymal enhancing lesions. The cerebrospinal fluid rapid plasma reagin and venereal disease research laboratory test were positive and consistent with syphilitic gumma, and...

Multifocal CNS infiltration of chronic lymphocytic leukemia in the form of small-cell solid metastatic lesions

Imitola, Jaime Pitt, Kelly Peoples, James L. Krynska, Barbara Sheikh, Hina Kesari, Santosh Azizi, S. Ausim

Published in Journal of Neuro-Oncology

Fourth ventricular choroid plexus papilloma

Mahta, Ali Kim, Ryan Y. Kesari, Santosh

Published in Medical Oncology

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