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Retrospective study of pemetrexed as salvage therapy for central nervous system lymphoma

Published in Journal of Neuro-Oncology

There is currently no standard therapy for recurrent or chemotherapy-refractory central nervous system lymphoma (CNSL). Pemetrexed has been reported to have activity in patients with primary CNSL (PCNSL). The use of pemetrexed in secondary CNS lymphoma (SCNSL) has not previously been reported. Here we retrospectively review the outcomes and toxicit...

Multifocal CNS infiltration of chronic lymphocytic leukemia in the form of small-cell solid metastatic lesions

Published in Journal of Neuro-Oncology

Pilocytic astrocytoma of the spinal cord in an adult

Published in Journal of Neuro-Oncology

Genomic profiling of glioblastoma: convergence of fundamental biologic tenets and novel insights

Published in Journal of Neuro-Oncology

With advances in genomic profiling and sequencing technology, we are beginning to understand the landscape of the genetic events that accumulated during the neoplastic process. The insights gleamed from these genomic profiling studies with regards to glioblastoma etiology has been particularly satisfying because it cemented the clinical pertinence ...

Chronic lymphocytic leukemia with central nervous system involvement: report of two cases with a comprehensive literatur...

Published in Journal of Neuro-Oncology

Central nervous system (CNS) involvement is a rare complication of chronic lymphocytic leukemia (CLL) with varied outcomes. We contribute two additional cases of CLL with CNS involvement. The clinical course and response to treatment are described. All 78 previously reported cases of CLL with CNS involvement are presented in this comprehensive revi...

Cell phones and glioma risk: a review of the evidence

Published in Journal of Neuro-Oncology

Concurrent intrathecal methotrexate and liposomal cytarabine for leptomeningeal metastasis from solid tumors: a retrospe...

Published in Journal of Neuro-Oncology

Leptomeningeal metastasis (LM) from solid tumors is typically a late manifestation of systemic cancer with limited survival. Randomized trials comparing single agent intrathecal methotrexate to liposomal cytarabine have shown similar efficacy and tolerability. We hypothesized that combination intrathecal chemotherapy would be a safe and tolerable o...

Novel approaches to treating leptomeningeal metastases

Published in Journal of Neuro-Oncology

Leptomeningeal metastasis is a devastating complication of the central nervous system in patients with late-stage solid or hematological cancers. Leptomeningeal metastasis results from the multifocal seeding of the leptomeninges by malignant cancer cells. Although central nervous system metastasis usually presents in patients with widely disseminat...