Wagner, Samuel C. Ichim, Thomas E. Ma, Hong Szymanski, Julia Perez, Jesus A. Lopez, Javier Bogin, Vladimir Patel, Amit N. Marincola, Francisco M. Kesari, Santosh
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Published in
Journal of Translational Medicine
Angiogenesis is essential for the growth and metastasis of solid tumors. The tumor endothelium exists in a state of chronic activation and proliferation, fueled by the tumor milieu where angiogenic mediators are aberrantly over-expressed. Uncontrolled tumor growth, immune evasion, and therapeutic resistance are all driven by the dysregulated and co...
Ichim, Thomas E Li, Shuang Ma, Hong Yurova, Yuliya V Szymanski, Julia S Patel, Amit N Kesari, Santosh Min, Wei-Ping Wagner, Samuel C
Published in
Journal of Translational Medicine
BackgroundWhile the concept of angiogenesis blockade as a therapeutic intervention for cancer has been repeatedly demonstrated, the full promise of this approach has yet to be realized. Specifically, drugs such as VEGF-blocking antibodies or kinase inhibitors suffer from the drawbacks of resistance development, as well as off-target toxicities. Pre...
Pingle, Sandeep C Sultana, Zeba Pastorino, Sandra Jiang, Pengfei Mukthavaram, Rajesh Chao, Ying Bharati, Ila Sri Nomura, Natsuko Makale, Milan Abbasi, Taher
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Published in
Journal of Translational Medicine
BackgroundGlioblastoma (GBM) is an aggressive disease associated with poor survival. It is essential to account for the complexity of GBM biology to improve diagnostic and therapeutic strategies. This complexity is best represented by the increasing amounts of profiling (“omics”) data available due to advances in biotechnology. The challenge of int...
Jiang, Pengfei Mukthavavam, Rajesh Chao, Ying Bharati, Ila Sri Fogal, Valentina Pastorino, Sandra Cong, Xiuli Nomura, Natsuko Gallagher, Matt Abbasi, Taher
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Published in
Journal of Translational Medicine
BackgroundGlioblastoma (GBM) is a therapeutic challenge, associated with high mortality. More effective GBM therapeutic options are urgently needed. Hence, we screened a large multi-class drug panel comprising the NIH clinical collection (NCC) that includes 446 FDA-approved drugs, with the goal of identifying new GBM therapeutics for rapid entry in...
Lyday, Bruce Chen, Tony Kesari, Santosh Minev, Boris
Published in
Journal of Translational Medicine
Combining dendritic cell vaccination with the adjuvant effect of a strain of dengue virus may be a way to overcome known tumor immune evasion mechanisms. Dengue is unique among viruses as primary infections carry lower mortality than the common cold, but secondary infections carry significant risk of hypovolemic shock. While current immuno-therapie...
Mukthavaram, Rajesh Ouyang, Xiao Saklecha, Rohit Jiang, Pengfei Nomura, Natsuko Pingle, Sandeep C Guo, Fang Makale, Milan Kesari, Santosh
Published in
Journal of Translational Medicine
BackgroundThe STAT3 transcription factor is a major intracellular signaling protein and is frequently dysregulated in the most common and lethal brain malignancy in adults, glioblastoma multiforme (GBM). Activation of STAT3 in GBM correlates with malignancy and poor prognosis. The phosphorylating signal transducer JAK2 activates STAT3 in response t...
