Zhu, Jian Larman, H Benjamin Gao, Geng Somwar, Romel Zhang, Zijuan Laserson, Uri Ciccia, Alberto Pavlova, Natalya Church, George Zhang, Wei
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Published in
Nature biotechnology
Identifying physical interactions between proteins and other molecules is a critical aspect of biological analysis. Here we describe PLATO, an in vitro method for mapping such interactions by affinity enrichment of a library of full-length open reading frames displayed on ribosomes, followed by massively parallel analysis using DNA sequencing. We d...
Larman, H Benjamin Zhao, Zhenming Laserson, Uri Li, Mamie Z Ciccia, Alberto Gakidis, M Angelica Martinez Church, George M Kesari, Santosh Leproust, Emily M Solimini, Nicole L
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Published in
Nature biotechnology
Immune responses targeting self-proteins (autoantigens) can lead to a variety of autoimmune diseases. Identification of these antigens is important for both diagnostic and therapeutic reasons. However, current approaches to characterize autoantigens have, in most cases, met only with limited success. Here we present a synthetic representation of th...
