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Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction.

Fogal, V Ivan Babic Chao, Y Pastorino, S Rajesh Mukthavaram Pengfei Jiang Cho, Yj Sandeep Pingle John Crawford Piccioni, De ...

Published in Oncotarget

Metabolic reprogramming is a key feature of tumorigenesis that is controlled by oncogenes. Enhanced utilization of glucose and glutamine are the best-established hallmarks of tumor metabolism. The oncogene c-Myc is one of the major players responsible for this metabolic alteration. However, the molecular mechanisms involved in Myc-induced metabolic...

Molecular inimitability amongst tumors: implications for precision cancer medicine in the age of personalized oncology.

Patel, Sp Schwaederle, M Daniels, Ga Fanta, Pt Schwab, Rb Shimabukuro, Ka Santosh Kesari Piccioni, De Bazhenova, La Helsten, Tl ...

Published in Oncotarget

Tumor sequencing has revolutionized oncology, allowing for detailed interrogation of the molecular underpinnings of cancer at an individual level. With this additional insight, it is increasingly apparent that not only do tumors vary within a sample (tumor heterogeneity), but also that each patient s individual tumor is a constellation of unique mo...

Detection rate of actionable mutations in diverse cancers using a biopsy-free (blood) circulating tumor cell DNA assay.

Schwaederle, M Husain, H Fanta, Pt Piccioni, De Santosh Kesari Schwab, Rb Banks, Kc Lanman, Rb Talasaz, A Parker, Ba ...

Published in Oncotarget

Analysis of cell-free DNA using next-generation sequencing (NGS) is a powerful tool for the detection/monitoring of alterations present in circulating tumor DNA (ctDNA). Plasma extracted from 171 patients with a variety of cancers was analyzed for ctDNA (54 genes and copy number variants (CNVs) in three genes (EGFR, ERBB2 and MET)). The most repres...

Plexin-B2 promotes invasive growth of malignant glioma.

Le, Ap Huang, Y Sandeep Pingle Santosh Kesari Wang, H Yong, Rl Zou, H Friedel, Rh

Published in Oncotarget

Invasive growth is a major determinant of the high lethality of malignant gliomas. Plexin-B2, an axon guidance receptor important for mediating neural progenitor cell migration during development, is upregulated in gliomas, but its function therein remains poorly understood. Combining bioinformatic analyses, immunoblotting and immunohistochemistry ...

Leptomeningeal metastasis in breast cancer - a systematic review.

Scott, Brian J Oberheim-Bush, Nancy A Kesari, Santosh

Published in Oncotarget

There is limited data on the impact of specific patient characteristics, tumor subtypes or treatment interventions on survival in breast cancer LM. A systematic review was conducted to assess the impact of hormone receptor and HER-2 status on survival in breast cancer LM. A search for clinical studies published between 1/1/2007 and 7/1/2012 and all...

A phase I trial of high dose gefitinib for patients with leptomeningeal metastases from non-small cell lung cancer.

Jackman, Dm Cioffredi, La Jacobs, L Sharmeen, F Morse, Lk Lucca, J Plotkin, Sr Marcoux, Pj Rabin, Ms Lynch, Tj ...

Published in Oncotarget

Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies.

Xiu, Joanne Piccioni, David Juarez, Tiffany Pingle, Sandeep C Hu, Jethro Rudnick, Jeremy Fink, Karen Spetzler, David B Maney, Todd Ghazalpour, Anatole ...

Published in Oncotarget

Glioblastomas (GBM) are the most aggressive and prevalent form of gliomas with abysmal prognosis and limited treatment options. We analyzed clinically relevant molecular aberrations suggestive of response to therapies in 1035 GBM tumors. Our analysis revealed mutations in 39 genes of 48 tested. IHC revealed expression of PD-L1 in 19% and PD-1 in 46...

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